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 Welcome to the website of the Angiogenesis Laboratory Amsterdam 

Angiogenesis is a key process in cancer. It is therefore a target in the development of novel anti-cancer therapies. The Angiogenesis Laboratory Amsterdam seeks to unravel the fundamental processes and mechanisms underlying angiogenesis and vascular development. The major aim is to use new knowledge and technology for the development of new treatment modalities in the clinic.


Angiogenesis has an unofficial impact factor: 5.470

 

Special issue of Angiogenesis 'Imaging of angiogenesis'

Guest editor: Dr. WJM. Mulder

 

Topics:

- Imaging vascular permeability and lymphatic drainage

- MR imaging to identify vulnerable atherosclerotic plaques

- Imaging angiogenesis in the brain after stroke

- Nanoparticle targeting in tumors

- Quantum dots for multimodal imaging of angiogenesis

- Optical imaging of angiogenesis

- MR imaging of head and neck squamous cell carcinoma

- Multimodal liposomes for imaging of angiogenesis

- Ultrasound based molecular imaging of angiogenesis

- Angiogenesis-specific perfluorocarbon nanoparticles

 


 

 

 

 

 

Endothelial cell tube formation

The workhorse assay of the Angiogenesis Laboratory.

 

 


Recent research Other recent findings

Isolation of tumor endothelial cells

Van Beijnum et al. Nature protocols, 2008

BBA - Reviews on Cancer on ScienceDirect(Opens new window)

MicroRNAs in the tumor endothelium: novel controls on the angioregulatory switchboard.

Heusschen et al., BBA Cancer, 2010.

Induction of tumour cell plasticity by the metalloprotease ADAMTS1.

Casal et al. Cancer Research, 2010

Angiostasis induced vascular normalization can improve photodynamic therapy.

Nowak-Sliwinska et al. Cell Mol Life Sci, 2010

BBA - Reviews on Cancer on ScienceDirect(Opens new window)

Signalling pathways in vasculogenic mimicry

Paulis et al. BBA Cancer, 2010

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

Gotink et al. Angiogenesis 2010

Making tumors vulnerable to the immune system by angiostasis.

Griffioen, Cancer Immunol. Immunother., 2008.

Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis.

Kluza et al. Nano Letters, 2010

A quantum dot-based probe for molecular imaging of angiogenesis.

Mulder et al. Nano Letters, 2006.

NF-kappaB in angiogenesis inhibition

Tabruyn & Griffioen, Cell Death Diff., 2007

 

No lymph angiogenesis in primary breast carcinoma.

Van der Schaft et al. Cancer Lett., 2007.

 

Anginex-labeled liposomes for targeting of tumor endothelium

Brandwijk et al. Bioconj Chem., 2007

Novel targets on tumor endothelial cells.

Van Beijnum et al. Blood, 2006.

 

Anti-angiogenesis enhances leukocyte infiltration in tumors.

Dirkx et al. FASEB J., 2006.

 

IL-21 a new angiogenesis inhibitor

Castermans et al., Blood, 2008


NEWS & EVENTS

The Angiogenesis Laboratory Amsterdam in the news (articles only in Dutch)


Tracer, April 2009

 

 

Medische Oncologie March, 2007 

 

 

De Volkskrant, September 9th, 2006

 

 

 

 

 

 

 

 

 

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Last updated on

 

August 28th, 2010

 

Mare, Leids Universitair weekblad, March, 2008

Chemisch Tijdschrift, March, 2007 C2W Life Scieces,

 

Summum, December 20th, 2006

© Bekkerlot 2006