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Welcome
to the website of the Angiogenesis Laboratory
Amsterdam
Angiogenesis is a key
process in cancer. It is therefore a target in the development of novel
anti-cancer therapies. The Angiogenesis Laboratory Amsterdam seeks to
unravel the fundamental
processes and mechanisms underlying angiogenesis and vascular
development. The major aim is to use new knowledge and technology for
the development of new treatment modalities in the clinic. |
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Angiogenesis has an unofficial impact factor:
5.470
 Special issue of Angiogenesis
'Imaging of angiogenesis'
Guest editor: Dr. WJM. Mulder
Topics:
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Imaging vascular permeability and lymphatic drainage
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MR imaging to identify vulnerable atherosclerotic plaques
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Imaging angiogenesis in the brain after stroke
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Nanoparticle targeting in tumors
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Quantum dots for multimodal imaging of angiogenesis
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Optical imaging of angiogenesis
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MR imaging of head and neck squamous cell carcinoma
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Multimodal liposomes for imaging of angiogenesis
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Ultrasound based molecular imaging of angiogenesis
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Angiogenesis-specific perfluorocarbon nanoparticles
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Endothelial cell tube formation
The workhorse assay of the
Angiogenesis Laboratory.
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Recent research
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Other recent findings |
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 Isolation
of tumor endothelial cells
Van Beijnum et al. Nature
protocols, 2008
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MicroRNAs in the tumor endothelium: novel controls on the
angioregulatory switchboard.
Heusschen et al.,
BBA Cancer, 2010. |
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 Induction
of tumour cell plasticity by the metalloprotease ADAMTS1.
Casal et al. Cancer Research, 2010 |
Angiostasis induced vascular
normalization can improve photodynamic therapy.
Nowak-Sliwinska
et al. Cell Mol Life Sci, 2010 |
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Signalling pathways in vasculogenic mimicry
Paulis et
al. BBA Cancer, 2010 |
Anti-angiogenic tyrosine kinase inhibitors: what
is their mechanism of action?
Gotink et al.
Angiogenesis 2010
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Making tumors vulnerable to
the immune system by angiostasis.
Griffioen,
Cancer Immunol. Immunother., 2008. |
Synergistic targeting of
alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic
liposomes for combined MR imaging and treatment of angiogenesis.
Kluza et al. Nano Letters,
2010
A quantum dot-based probe for
molecular imaging of angiogenesis.
Mulder et
al. Nano Letters, 2006.
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NF-kappaB in angiogenesis inhibition
Tabruyn &
Griffioen, Cell Death Diff., 2007
No
lymph angiogenesis in primary breast carcinoma.
Van der Schaft et al. Cancer Lett., 2007.
Anginex-labeled liposomes for targeting of tumor endothelium
Brandwijk et al. Bioconj Chem., 2007
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Novel targets on tumor endothelial cells.
Van Beijnum et al.
Blood, 2006.
Anti-angiogenesis enhances
leukocyte infiltration in tumors.
Dirkx et al. FASEB J.,
2006.
IL-21 a new angiogenesis
inhibitor
Castermans et
al., Blood, 2008 |
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NEWS & EVENTS
The Angiogenesis Laboratory
Amsterdam in
the news (articles only in Dutch)
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Tracer, April 2009
Medische
Oncologie March, 2007
De Volkskrant, September 9th, 2006
You are visitor
 Last updated on
August 28th, 2010
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Mare, Leids Universitair
weekblad, March, 2008
Chemisch Tijdschrift, March, 2007 C2W
Life Scieces,
Summum,
December 20th, 2006 |
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